Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.

@article{Shinozuka2002FeedingOG,
  title={Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.},
  author={Kazumasa Shinozuka and Keizo Umegaki and Yoko Kubota and Naoko Tanaka and Hideya Mizuno and Jun Yamauchi and Kazuki Nakamura and Masaru Kunitomo},
  journal={Life sciences},
  year={2002},
  volume={70 23},
  pages={
          2783-92
        }
}
Ginkgo biloba extract (GBE) has been used clinically for improving peripheral vascular diseases in France and Germany and is ingested widely as a herbal medicine in some countries. However, accurate information about its safety as an herbal medicine has not been sufficiently established. To address this issue, we examined the effect of GBE on hepatic drug metabolizing enzymes and their influence on hypotensive drug in rats. Male rats were fed either a control diet or diet containing GBE (0.5% w… CONTINUE READING

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