Feeding by the tick, Ixodes scapularis, causes CD4(+) T cells responding to cognate antigen to develop the capacity to express IL-4.

@article{MllerDoblies2007FeedingBT,
  title={Feeding by the tick, Ixodes scapularis, causes CD4(+) T cells responding to cognate antigen to develop the capacity to express IL-4.},
  author={Uwe U M{\"u}ller-Doblies and Samuel Steen Maxwell and Venkata D. Boppana and Marianne A. Mihalyo and Stephen J McSorley and Anthony T. Vella and Adam J Adler and Stephen K. Wikel},
  journal={Parasite immunology},
  year={2007},
  volume={29 10},
  pages={485-99}
}
Effects of tick feeding on an early antigen-specific T cell response were studied by monitoring a clonotypic population of adoptively transferred T cell receptor (TCR) transgenic CD4 cells responding to a tick-associated antigen. When recipient mice were infested with pathogen-free Ixodes scapularis nymphs several days prior to T cell transfer and intradermal injection of soluble cognate antigen at the feeding site, the clonotypic CD4 cells gained the ability to express the Th2 effector… CONTINUE READING

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