Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions.

@article{Lee2007FeedingAI,
  title={Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions.},
  author={M D Lee and Rong-Ze Yang and Da-Wei Gong and Susan K. Fried},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 1},
  pages={72-80}
}
The post-transcriptional mechanisms by which feeding and insulin increase leptin production are poorly understood. Starvation of 6-7-week-old rats for 14 h decreased leptin mRNA level by only 22% but decreased plasma levels, adipose tissue leptin content, and release by over 75%. The decreased leptin with starvation was explained by >85% decrease in relative rates of leptin biosynthesis measured by metabolic labeling and immunoprecipitation. In vitro insulin treatment of adipose tissue from fed… CONTINUE READING
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