Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model

@inproceedings{Grigura2018FeedingAS,
  title={Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model},
  author={Vadim Grigura and Megan Barbier and Anna P Zarov and Charles K Kaufman},
  booktitle={Biology open},
  year={2018}
}
The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to 'tune' the system to more quickly… CONTINUE READING
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