Feedforward regulation ensures stability and rapid reversibility of a cellular state.

  title={Feedforward regulation ensures stability and rapid reversibility of a cellular state.},
  author={Andreas Doncic and Jan M Skotheim},
  journal={Molecular cell},
  volume={50 6},
Cellular transitions are important for all life. Such transitions, including cell fate decisions, often employ positive feedback regulation to establish and stabilize new cellular states. However, positive feedback is unlikely to underlie stable cell-cycle arrest in yeast exposed to mating pheromone because the signaling pathway is linear, rather than bistable, over a broad range of extracellular pheromone concentration. We show that the stability of the pheromone-arrested state results from… CONTINUE READING

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