Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA

@inproceedings{Warren2012FeederFreeDO,
  title={Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA},
  author={Luigi Warren and Yuhui Ni and Jiwu Wang and Xi-rong Guo},
  booktitle={Scientific reports},
  year={2012}
}
The therapeutic promise of induced pluripotent stem cells (iPSCs) has spurred efforts to circumvent genome alteration when reprogramming somatic cells to pluripotency. Approaches based on episomal DNA, Sendai virus, and messenger RNA (mRNA) can generate "footprint-free" iPSCs with efficiencies equaling or surpassing those attained with integrating viral vectors. The mRNA method uniquely affords unprecedented control over reprogramming factor (RF) expression while obviating a cleanup phase to… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…