Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.

@article{Hwang2014FeedbackRV,
  title={Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.},
  author={Ara B. Hwang and Eun-A Ryu and Murat Artan and Hsin-Wen Ella Chang and Mohammad Humayun Kabir and Hyun-Jun Nam and Dongyeop Lee and Jae-Seong Yang and Sanguk Kim and William B. Mair and Cheolju Lee and Siu Sylvia Lee and Seung-Jae V Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 42},
  pages={E4458-67}
}
Mild inhibition of mitochondrial respiration extends the lifespan of many species. In Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-inducible factor 1 (HIF-1) in response to reduced mitochondrial respiration. However, the physiological role and mechanism of ROS-induced longevity are poorly understood. Here, we… CONTINUE READING