Feedback regulation of ribosomal protein gene expression in Escherichia coli: structural homology of ribosomal RNA and ribosomal protein MRNA.

@article{Nomura1980FeedbackRO,
  title={Feedback regulation of ribosomal protein gene expression in Escherichia coli: structural homology of ribosomal RNA and ribosomal protein MRNA.},
  author={M Nomura and J L Yates and D Dean and L E Post},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 12},
  pages={7084-8}
}
  • M Nomura, J L Yates, +1 author L E Post
  • Published 1980 in
    Proceedings of the National Academy of Sciences…
Certain ribosomal proteins (r proteins) in Escherichia coli, such as S4 and S7, function as feedback repressors in the regulation of r-protein synthesis. These proteins inhibit the translation of their own mRNA. The repressor r proteins so far identified are also known to bind specifically to rRNA at an initial stage in ribosome assembly. We have found structural homology between the S7 binding region on 16S rRNA and a region of the mRNA where S7 acts as a translational repressor. Similarly… CONTINUE READING