Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.

@inproceedings{Ellis2003FeedbackRO,
  title={Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.},
  author={Ewa Ellis and Magnus Axelson and Anna Abrahamsson and G{\"o}sta Eggertsen and Anders Th{\"o}rne and Grzegorz A. Nowak and B. Ericzon and Ingemar Bj{\"o}rkhem and Curt Einarsson},
  year={2003}
}
Abstract Primary human hepatocytes were used to elucidate the effect of individual bile acids on bile acid formation in human liver. Hepatocytes were treated with free as well as glycine-conjugated bile acids. Bile acid formation and messenger RNA (mRNA) levels of key enzymes and the nuclear receptor short heterodimer partner (SHP) were measured after 24 hours. Glycochenodeoxycholic acid (GCDCA; 100 μmol/L) significantly decreased formation of cholic acid (CA) to 44% ± 4% of controls and… CONTINUE READING

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