Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.

@article{Ellis2003FeedbackRO,
  title={Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.},
  author={Ewa C S Ellis and Magnus Axelson and Anna Abrahamsson and G{\"o}sta Eggertsen and Anders Th{\"o}rne and Grzegorz Nowak and Bo-G{\"o}ran Ericzon and Ingemar Bj{\"o}rkhem and Curt Einarsson},
  journal={Hepatology},
  year={2003},
  volume={38 4},
  pages={930-8}
}
Primary human hepatocytes were used to elucidate the effect of individual bile acids on bile acid formation in human liver. Hepatocytes were treated with free as well as glycine-conjugated bile acids. Bile acid formation and messenger RNA (mRNA) levels of key enzymes and the nuclear receptor short heterodimer partner (SHP) were measured after 24 hours… CONTINUE READING