Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II.

@article{Schunkert1993FeedbackRO,
  title={Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II.},
  author={Heribert Schunkert and Julie R. Ingelfinger and Alan T. Hirsch and Yigal M. Pinto and Willem J. Remme and Howard Jacob and Victor J. Dzau},
  journal={Circulation research},
  year={1993},
  volume={72 2},
  pages={312-8}
}
Although renin and angiotensinogen are known to be subject to feedback regulation, the effects of angiotensin II (Ang II) on the regulation of angiotensin converting enzyme (ACE) gene expression and enzymatic activity have not yet been studied. Therefore, the effects of exogenous Ang II infusion and ACE inhibition on ACE mRNA expression were examined. Ang II was infused intravenously in male Sprague-Dawley rats for 3 days at 100 (low dose), 300 (medium dose), or 1,000 (high dose) ng/kg per… CONTINUE READING
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