Feedback motif for the pathogenesis of Parkinson's disease.

@article{Cloutier2012FeedbackMF,
  title={Feedback motif for the pathogenesis of Parkinson's disease.},
  author={Mathieu Cloutier and Ryan C Middleton and Peter Wellstead},
  journal={IET systems biology},
  year={2012},
  volume={6 3},
  pages={
          86-93
        }
}
Previous article on the integrative modelling of Parkinson's disease (PD) described a mathematical model with properties suggesting that PD pathogenesis is associated with a feedback-induced biochemical bistability. In this article, the authors show that the dynamics of the mathematical model can be extracted and distilled into an equivalent two-state feedback motif whose stability properties are controlled by multi-factorial combinations of risk factors and genetic mutations associated with PD… CONTINUE READING
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