Feedback mechanism for microtubule length regulation by stathmin gradients.

Abstract

We formulate and analyze a theoretical model for the regulation of microtubule (MT) polymerization dynamics by the signaling proteins Rac1 and stathmin. In cells, the MT growth rate is inhibited by cytosolic stathmin, which, in turn, is inactivated by Rac1. Growing MTs activate Rac1 at the cell edge, which closes a positive feedback loop. We investigate… (More)
DOI: 10.1016/j.bpj.2014.10.056

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