Feedback inhibition of deoxy-D-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathway.

@article{Banerjee2013FeedbackIO,
  title={Feedback inhibition of deoxy-D-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathway.},
  author={Aparajita Banerjee and Yan Wu and Rahul Banerjee and Yue Li and Honggao Yan and Thomas D Sharkey},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 23},
  pages={16926-36}
}
The 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway leads to the biosynthesis of isopentenyl diphosphate (IDP) and dimethylallyl diphosphate (DMADP), the precursors for isoprene and higher isoprenoids. Isoprene has significant effects on atmospheric chemistry, whereas other isoprenoids have diverse roles ranging from various biological processes to applications in commercial uses. Understanding the metabolic regulation of the MEP pathway is important considering the numerous applications of… CONTINUE READING