Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin

@article{Pan2007FeedbackIO,
  title={Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin},
  author={Fan Pan and Luo Sun and David B. Kardian and Katharine A Whartenby and Drew Mark Pardoll and Jun O Liu},
  journal={Nature},
  year={2007},
  volume={445},
  pages={433-436}
}
Feedback regulation of adaptive immunity is a fundamental mechanism for controlling the overall output of different signal transduction pathways, including that mediated by the T-cell antigen receptor (TCR). Calcineurin and Ras are known to have essential functions during T-cell activation. However, how the calcineurin signalling pathway is terminated in… CONTINUE READING