Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.

@article{Tsubouchi2001FeedbackCO,
  title={Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.},
  author={Yasunori Tsubouchi and Yutaka Kawahito and Masataka Kohno and K Inoue and Timothy Hla and Hajime Sano},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={283 4},
  pages={
          750-5
        }
}
Rheumatoid arthritis (RA) is a chronic polyarticular joint disease associated with massive synovial proliferation, inflammation, and angiogenesis. PPAR-gamma ligands, both 15-deoxy-Delta(12,14)-prostaglandin J2 (15d- PGJ2) and troglitazone (TRO), can inhibit the growth of RA synoviocytes in vitro, and suppress the chronic inflammation of adjuvant-induced arthritis in rats, but the potency of 15d-PGJ2 is higher than TRO. Prostaglandin (PG) E2 plays important roles in joint erosion and synovial… Expand
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