Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis.

@article{Zartman2009FeedbackCO,
  title={Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis.},
  author={Jeremiah J. Zartman and Jitendra S. Kanodia and L. S. Cheung and Stanislav Y. Shvartsman},
  journal={Development},
  year={2009},
  volume={136 17},
  pages={2903-11}
}
The morphogenesis of structures with repeated functional units, such as body segments and appendages, depends on multi-domain patterns of cell signaling and gene expression. We demonstrate that during Drosophila oogenesis, the two-domain expression pattern of Broad, a transcription factor essential for the formation of the two respiratory eggshell appendages, is established by a single gradient of EGFR activation that induces both Broad and Pointed, which mediates repression of Broad. Two… CONTINUE READING