Feedback control of cyclooxygenase-2 expression through PPARgamma.

  title={Feedback control of cyclooxygenase-2 expression through PPARgamma.},
  author={Hiroyasu Inoue and Tadashi Tanabe and Kazuhiko Umesono},
  journal={The Journal of biological chemistry},
  volume={275 36},
Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandins (PG), plays a key role in inflammation, tumorigenesis, development, and circulatory homeostasis. The PGD(2) metabolite 15-deoxy-Delta(12, 14) PGJ(2) (15d-PGJ(2)) was identified as a potent natural ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). PPARgamma expressed in macrophages has been postulated as a negative regulator of inflammation and a positive regulator of differentiation into foam cell… CONTINUE READING


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