Feedback between p21 and reactive oxygen production is necessary for cell senescence

  title={Feedback between p21 and reactive oxygen production is necessary for cell senescence},
  author={Jo{\~a}o F. Passos and Glyn Nelson and Chunfang Wang and Torsten Richter and Cedric Simillion and Carole J. Proctor and Satomi Miwa and Sharon Olijslagers and Jennifer S. Hallinan and Anil Wipat and Gabriele Saretzki and Karl Lenhard Rudolph and T. B. Kirkwood and Thomas von Zglinicki},
  booktitle={Molecular systems biology},
Cellular senescence--the permanent arrest of cycling in normally proliferating cells such as fibroblasts--contributes both to age-related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism. The pathways leading to establishment of senescence are proving to be more complex than was previously envisaged. Combining in-silico interactome analysis and functional target gene inhibition, stochastic modelling and live cell microscopy, we show here that there exists a dynamic… CONTINUE READING


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DNAdamage in telomeres andmitochondria during cellular senescence: is there a connection

  • J Passos, G Saretzki, T Von Zglinicki
  • Nucleic Acids Res
  • 2007
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