Feedback Loops Shape Cellular Signals in Space and Time

@article{Brandman2008FeedbackLS,
  title={Feedback Loops Shape Cellular Signals in Space and Time},
  author={Onn Brandman and Tobias Meyer},
  journal={Science},
  year={2008},
  volume={322},
  pages={390 - 395}
}
Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems. 
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