Feedback Control of Cyclooxygenase-2 Expression through PPAR g *

  title={Feedback Control of Cyclooxygenase-2 Expression through PPAR g *},
  author={Hiroyasu Inoue and Tadashi Tanabe and Kazuhiko Umesono},
Cyclooxygenase-2 (COX-2), a rate-limiting enzyme for prostaglandins (PG), plays a key role in inflammation, tumorigenesis, development, and circulatory homeostasis. The PGD2 metabolite 15-deoxy-D 12,14 PGJ2 (15dPGJ2) was identified as a potent natural ligand for the peroxisome proliferator-activated receptor-g (PPARg). PPARg expressed in macrophages has been postulated as a negative regulator of inflammation and a positive regulator of differentiation into foam cell associated with… CONTINUE READING
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