Feedback Activation of STAT3 as a Cancer Drug-Resistance Mechanism.

Abstract

Signal transducer and activator of transcription 3 (STAT3) plays crucial roles in several cellular processes such as cell proliferation and survival, and has been found to be aberrantly activated in many cancers. Much research has explored the leading mechanisms for regulating the STAT3 pathway and its role in promoting tumorigenesis. We focus here on… (More)
DOI: 10.1016/j.tips.2015.10.001

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