Fecal microbiota transplant treatment for recurrent Clostridioides difficile infection enhances adaptive immunity to TcdB.

  title={Fecal microbiota transplant treatment for recurrent Clostridioides difficile infection enhances adaptive immunity to TcdB.},
  author={Laura Cook and William D Rees and May Q. Wong and Hannah Peters and Megan K. Levings and Theodore S. Steiner},
3 Citations

Apple Polyphenol Extract Suppresses Clostridioides difficile Infection in a Mouse Model

The results suggest that apple polyphenol extract is a potential prebiotic agent that affects the intestinal microbiota and metabolism, thereby positively influencing intestinal infections.

Fecal Microbiota Transplantation Increases Colonic IL-25 and Dampens Tissue Inflammation in Patients with Recurrent Clostridioides difficile

What immune markers are changed in patients undergoing FMT to treat recurrent C. difficile infection is sought to understand and an immune signaling molecule, IL-25, that was restored by FMT is identified.



Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity

Different IL-17–secreting T cell subsets are discussed, emphasizing their regulation and function in oropharyngeal candidiasis and periodontitis and their role in protective immunity and inflammation in the oral mucosa.

Update of treatment algorithms for Clostridium difficile infection.

  • R. OoijevaarY. V. van Beurden E. Kuijper
  • Medicine, Biology
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2018

Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines

By combining antigenic stimulation and T cell receptor deep sequencing, this work finds that human pathogen- and vaccine-specific T helper 1 (TH1), TH2, and TH17 memory cells have different frequencies but comparable diversity and comprise not only clones polarized toward a single fate, but also clones whose progeny have acquired multiple fates.

Burden of Clostridium difficile infection in the United States.

C. difficile was responsible for almost half a million infections and was associated with approximately 29,000 deaths in 2011, and the North American pulsed-field gel electrophoresis type 1 (NAP1) strain was more prevalent among health care-associated infections than among community- associated infections.

Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense

Mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire is linked to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense.

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.

Among adults with recurrent or refractory CDI, the use of frozen compared with fresh FMT did not result in worse proportion of clinical resolution of diarrhea, and its use is a reasonable option in this setting.

Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance

It is suggested that protection from viral persistence upon HCV reinfection is associated with focusing of the HCV-specific CD8 memory T cell repertoire from which established cell lines showed high functional avidity.

Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections

Treatment of patients with CDI should be stratified depending on whether they have mild-to-moderate, severe, or complicated disease, and a classification of disease severity is proposed to guide therapy that is useful for clinicians.