Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

@article{Baruch2020FecalMT,
  title={Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients},
  author={Erez Nissim Baruch and Ilan Youngster and Guy Ben-betzalel and Rona Ortenberg and Adi Lahat and Lior H Katz and K M Adler and Daniela Dick-Necula and Stephen P. Raskin and Naamah Bloch and Daniil Rotin and Liat Anafi and Camila Avivi and Jenny Melnichenko and Yael Steinberg-Silman and Ronac Mamtani and Hagit Harati and Nethanel Asher and Ronnie Shapira-Frommer and Tal Brosh-Nissimov and Yael Eshet and Shira Ben-Simon and Oren Ziv and Md Abdul Wadud Khan and Moran Amit and Nadim J. Ajami and Iris Barshack and Jacob Schachter and Jennifer A. Wargo and Omry Koren and Gal Markel and Ben Boursi},
  journal={Science},
  year={2020},
  volume={371},
  pages={602 - 609}
}
New fecal microbiota for cancer patients The composition of the gut microbiome influences the response of cancer patients to immunotherapies. Baruch et al. and Davar et al. report first-in-human clinical trials to test whether fecal microbiota transplantation (FMT) can affect how metastatic melanoma patients respond to anti–PD-1 immunotherapy (see the Perspective by Woelk and Snyder). Both studies observed evidence of clinical benefit in a subset of treated patients. This included increased… 

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TLDR
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Fecal microbiota transplantation for immunotherapy‐resistant urological tumors: Is it time? An update of the recent literature

TLDR
The aim of this commentary is to highlight the potential for FMT in urological tumors (UC, RCC, and PCa) resistant to ICIs and to provide the evidence behind this distinct breakthrough.

Blood microbiota diversity determines response of advanced colorectal cancer to chemotherapy combined with adoptive T cell immunotherapy

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The diversity of the blood microbiome is a promising predictive marker for clinical responses to chemotherapy combined with DC-CIK, and more diverse blood microbiota that included Bifidobacterium, Lactobacillus, and Enterococcus were identified amongresponders compared with non-responders.
...

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