Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection in 26 Patients: Methodology and Results

@article{Kelly2012FecalMT,
  title={Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection in 26 Patients: Methodology and Results},
  author={Colleen R. Kelly and Lauren de Leon and Niren Jasutkar},
  journal={Journal of Clinical Gastroenterology},
  year={2012},
  volume={46},
  pages={145–149}
}
Goals: We aim to present a data detailing our success with fecal microbiota transplantation (FMT) and to provide a simple treatment protocol. Background: Relapse is a common problem in patients treated for Clostridium difficile infection, often requiring prolonged courses of oral vancomycin with limited alternative treatment options. Administration of the entire fecal flora from a healthy individual to restore beneficial physiological species is referred to as FMT (also termed fecal… 
Fecal Microbiota Transplantation Is Superior to Fidaxomicin for Treatment of Recurrent Clostridium difficile Infection.
TLDR
In a single-center randomized trial of patients with rCDI, the FMTv combination superior to fidaxomicin or vancomycin based on end points of clinical and microbiological resolution or clinical resolution alone was found.
Faecal microbiota transplantation and bacteriotherapy for recurrent Clostridium difficile infection: A retrospective evaluation of 31 patients
TLDR
FMT was found to be effective in patients with recurrent CDI and RBT based on a predefined bacterial suspension was as effective as or better than FMT based on faecal donation; however, multiple installations may be needed.
Faecal microbiota transplantation: a review of FMT as an alternative treatment for Clostridium difficile infection
TLDR
FMT appears to be a safe, highly efficacious and affordable treatment option for Clostridium difficile infection and future research should focus on potential long-term safety concerns and optimizing protocols for donor screening, patient selection and FMT administration.
A Retrospective Comparison of Fecal Microbial Transplantation Methods for Recurrent Clostridium Difficile Infection.
TLDR
Lower GI tract FMT is a safe and effective treatment for refractory and recurrent CDI, and yields quicker results than upper GI tractfecal microbiota transplantation.
Fecal microbiota transplantation via colonoscopy for recurrent C. difficile Infection.
TLDR
A systematic approach to patient and donor screening, preparation of stool, and delivery of the stool maximizes therapeutic success and yields excellent cure rates and is also well tolerated.
Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study.
  • I. Youngster, J. Sauk, +7 authors E. Hohmann
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2014
TLDR
In the initial feasibility study, FMT using a frozen inoculum from unrelated donors is effective in treating relapsing CDI and NGT administration appears to be as effective as colonoscopy administration.
Fecal microbiota transplant for Clostridium difficile infection in older adults
TLDR
FMT is a generally safe and effective treatment option for older adults with CDI and was not a causative factor in these events.
Fecal microbiota transplant in patients with Clostridium difficile infection: A systematic review
BACKGROUND Fecal microbiota transplantation (FMT) restores a diverse bacterial profile to the gastrointestinal tract and may effectively treat patients with Clostridium difficile infection (CDI). The
Treatment of relapsing Clostridium difficile infection using fecal microbiota transplantation
TLDR
FMT is a cheap, easily available, effective therapy for recurrent CDI; it can be safely performed in a community hospital setting with similar results.
Long-Term Follow-Up of Colonoscopic Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection
TLDR
FMT is a rational, durable, safe, and acceptable treatment option for patients with recurrent CDI and while no definite adverse effects of FMT were noted, two patients had improvement in a pre-existing medical condition and four patients developed diseases of potential interest after FMT.
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