Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

  title={Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze},
  author={Merci Kusel and Tatiana Kebadze and Sebastian L. Johnston and Patrick G. Holt and Peter D. Sly},
  journal={European Respiratory Journal},
  pages={876 - 882}
Severe viral respiratory illnesses and atopy are risk factors for childhood wheezing and asthma. The aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with wheeze and asthma persisting into later childhood. 147 children at high atopic risk were followed from birth to age 10 yrs. Data on all respiratory infections occurring in infancy were collected prospectively and viral aetiology ascertained. Atopy was measured by skin prick tests… 
Rhinovirus infections in infancy and early childhood
An overview on the role of RVs as important disease-causing agents from infancy to early childhood is provided and their contribution to the subsequent development of childhood wheeze and/or asthma is discussed.
Association of Rhinovirus C Bronchiolitis and Immunoglobulin E Sensitization During Infancy With Development of Recurrent Wheeze.
This multicenter cohort study of infants hospitalized for bronchiolitis demonstrated between-virus differences in the risk of developing recurrent wheeze, and found that infants with both rhinovirus C infection and IgE sensitization during infancy had significantly higher risks of recurrent Wheeze.
Pneumonia in Childhood and Impaired Lung Function in Adults: A Longitudinal Study
Early pneumonia is associated with asthma and impaired airway function, which is partially reversible with bronchodilators and persists into adulthood, and may be a major risk factor for adult chronic obstructive pulmonary disease.
Which is the principal early-life infection-related risk factor for asthma?
The drop-out rate of 44% is understandable but needs evaluation, and the data were collected very carefully during the first year including diaries completed by parents and home visits with sampling for virus detection by PCR during all acute infections.
Longitudinal Associations Between Respiratory Infections and Asthma in Young Children
It is suggested that asthma at age 6 years is directly influenced by asthma history and only indirectly, if at all, by earlier infection episodes, and little support for a protective effect of preschool infections on asthma at early school age.
Early Respiratory Infections and the Development of Asthma in the First 27 Years of Life.
Investigation of early-life respiratory infections as predictors of the development of asthma in a 20-year prospective cohort study provides new evidence that respiratory tract infections in early life predict theDevelopment of asthma through childhood to young adulthood.


Rhinovirus illnesses during infancy predict subsequent childhood wheezing.
Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children.
Among outpatient viral wheezing illnesses in infancy and early childhood, those caused by RV infections are the most significant predictors of the subsequent development of asthma at age 6 years in a high-risk birth cohort.
The majority of infants with wheeze have transient conditions associated with diminished airway function at birth and do not have increased risks of asthma or allergies later in life, but in a substantial minority of infants, however, wheezing episodes are probably related to a predisposition to asthma.
Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children.
Findings suggest that a subgroup of children with a triggering or inducing of asthmatic symptoms through repeated early childhood infections exists within the "asthma syndrome" which has a better prognosis and is less related to the atopic phenotype.
Asthma and wheezing in the first six years of life. The Group Health Medical Associates.
Children who started wheezing in early life and continued to wheeze at the age of six were more likely than the children who never wheezed to have mothers with a history of asthma, but do not have increased risks of asthma or allergies later in life.
Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence.
RATIONALE The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson,