Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.

@article{Ardley2001FeaturesOT,
  title={Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.},
  author={Helen C. Ardley and Nancy G S Tan and Stephen A. Rose and Alex F. Markham and Philip J. Robinson},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 22},
  pages={19640-7}
}
We recently reported the identification of a RING finger-containing protein, HHARI (human homologue of Drosophila ariadne), which binds to the human ubiquitin-conjugating enzyme UbcH7 in vitro. We now demonstrate that HHARI interacts and co-localizes with UbcH7 in mammalian cells, particularly in the perinuclear region. We have further defined a minimal interaction region of HHARI comprising residues 186-254, identified individual amino acid residues essential for the interaction, and… CONTINUE READING

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Defining the HHARI/UbcH7 Minimal Binding Region 19647 by on A ril 14

C.R.M. Wilkinson, M. Wallace, +6 authors C. Gordon
EMBO J. 17, • 1998
View 1 Excerpt

Ubiquitin and the Biology of the Cell

Nature Medicine • 1998
View 1 Excerpt

Cytogenet

T. P. Moynihan, C. G. Cole, +4 authors P. A. Robinson
Cell Genet . • 1997

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