Features of the (Na, K)-ATPase of cardiac sarcolemma with particular reference to myocardial ischaemia.

@article{Vrbjar1991FeaturesOT,
  title={Features of the (Na, K)-ATPase of cardiac sarcolemma with particular reference to myocardial ischaemia.},
  author={Norbert Vrbjar and J{\'a}n Slez{\'a}k and Attila Ziegelhoffer and Narcisa Tribulov{\'a}},
  journal={European heart journal},
  year={1991},
  volume={12 Suppl F},
  pages={149-52}
}
The role and regulation of (Na, K)-ATPase in cardiac sarcolemma are relatively well recognized today. Less abundant information is available about the time sequence of ischaemia-induced changes in activity and properties of the enzyme. In our experiments global ischaemia to the rat heart induces a time-dependent decrease in the activity and maximum velocity (Vm) value of sarcolemmal (Na, K)-ATPase. The depression of enzyme activity is fast and is expressed as early as 15 min after the onset of… CONTINUE READING