Features of responding T cells in cancer and chronic infection.

  title={Features of responding T cells in cancer and chronic infection.},
  author={Peter Sungwhan Kim and Rafi Ahmed},
  journal={Current opinion in immunology},
  volume={22 2},
Ever since T cell exhaustion was initially characterized and thoroughly analyzed in the murine LCMV model, such a functional impairment has been validated in other chronic viral infections such as HIV, HCV, and HBV. In tumor immunology, it has always been postulated that tumor-reactive T cells could also become functionally exhausted owing to the high tumor-antigen load and accompanying inhibitory mechanisms. However, the empirical evidences for this hypothesis have not been as extensive as in… CONTINUE READING