Features of genomic organization in a nucleotide-resolution molecular model of the Escherichia coli chromosome

@inproceedings{Hacker2017FeaturesOG,
  title={Features of genomic organization in a nucleotide-resolution molecular model of the Escherichia coli chromosome},
  author={William C. Hacker and Shuxiang Li and Adrian H. Elcock},
  booktitle={Nucleic acids research},
  year={2017}
}
We describe structural models of the Escherichia coli chromosome in which the positions of all 4.6 million nucleotides of each DNA strand are resolved. Models consistent with two basic chromosomal orientations, differing in their positioning of the origin of replication, have been constructed. In both types of model, the chromosome is partitioned into plectoneme-abundant and plectoneme-free regions, with plectoneme lengths and branching patterns matching experimental distributions, and with… CONTINUE READING

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