Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation

  title={Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation},
  author={Sandra Leit-Ao Silva and Ana Rita Vaz and Andreia Pereira Barateiro and Ana Sofia Falc{\~a}o and Dora Brites},
  journal={Neurobiology of Disease},
Microglia constitute the brain's immunocompetent cells and are intricately implicated in numerous inflammatory processes included in neonatal brain injury. In addition, clearance of tissue debris by microglia is essential for tissue homeostasis and may have a neuroprotective outcome. Since unconjugated bilirubin (UCB) has been proven to induce astroglial immunological activation and neuronal cell death, we addressed the question of whether microglia acquires a reactive phenotype when challenged… CONTINUE READING


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