Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?

@article{Ponikau2003FeaturesOA,
  title={Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?},
  author={J. Ponikau and D. Sherris and G. Kephart and E. Kern and T. Gaffey and J. Tarara and H. Kita},
  journal={The Journal of allergy and clinical immunology},
  year={2003},
  volume={112 5},
  pages={
          877-82
        }
}
BACKGROUND Asthma and chronic rhinosinusitis (CRS) coexist clinically in >50% of patients with CRS. Although epithelial damage and basement membrane thickening are well-known features of airway remodeling in asthma, they have not been described in CRS. OBJECTIVE In this study, we tested the hypothesis that histopathologic features of asthma, namely, the chronic eosinophilic inflammation, epithelial damage, and basement membrane thickening of the airway mucosa, are also present in sinonasal… Expand
Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis.
TLDR
It is suggested that eosinophils that infiltrate into both the epithelial and subepithelial layers play a part in the process of mucosal remodeling of CRS with nasal polyps. Expand
Advances in the Knowledge of the Underlying Airway Remodeling Mechanisms in Chronic Rhinosinusitis Based on the Endotypes: A Review
TLDR
Differences in tissue remodeling in CRS are suggested to be based on the clinical phenotype and endotypes; this is because fibrosis is prominent in C RSsNP, whereas edematous changes occur inCRSwNP, especially in the eosinophilic type. Expand
Pediatric Chronic Rhinosinusitis Histopathology
TLDR
The marked differences in the inflammatory response of children and adults with CRS may attest to different pathophysiologic pathways and is probably associated with diminished tissue eosinophilia. Expand
Nasal lavage cytology and mucosal histopathological alterations in patients with rhinitis.
TLDR
Upper airway remodeling accessed by basement membrane thickness showed similar inflammatory cell infiltrate in the nasal lavage, regardless of the presence of atopy, and 4% was the cutoff point for the number of eosinophils in the noses, for atopy differentiation. Expand
Mucosal Remodeling in Chronic Rhinosinusitis
TLDR
Increased BM thickness is correlated with prolonged duration of symptoms and the coincidence of asthma, which may indicate paranasal sinus remodeling akin to that which occurs in the bronchioles of persistent asthmatic sufferers. Expand
Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis.
TLDR
In patients with CRS, eosinophils form clusters in the mucus where they release MBP, which is diffusely deposited on the epithelium, a process not observed in the tissue. Expand
Neuropathology of the Olfactory Mucosa in Chronic Rhinosinusitis
TLDR
It is suggested that OM pathology observed in nasal biopsy specimens can assist in understanding the degree of epithelial change and sensorineural damage in CRS and the potential for olfactory loss. Expand
Histopathological Features of Chronic Rhinosinusitis with Nasal Allergic Polyps
TLDR
The most important stromal changes were edema in 88% and infiltration with eosinophils 100%, indicating the allergic nature of this disease. Expand
Role of Interleukin-17A in the Eosinophil Accumulation and Mucosal Remodeling in Chronic Rhinosinusitis with Nasal Polyps Associated with Asthma
TLDR
It is suggested, for the first time, that IL-17A plays an important role in the eosinophil accumulation in the nasal polyps and the remodeling of the nasalpolyps of chronic rhinosinusitis associated with asthma. Expand
Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps
TLDR
Although several features of remodeling are seen in both subgroups of CRS, epithelial shedding as observed in asthma is not seen in either subgroup, and pseudocyst formation seen in CRS without and CRS with nasal polyps is notseen. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
A clinical and pathologic study of chronic sinusitis: the role of the eosinophil.
TLDR
It is suggested that sinus disease in patients with asthma may be due to the same mechanisms that cause damage to bronchial epithelium, and the eosinophil acts as an effector cell in chronic inflammatory disease of paranasal respiratory epithelia. Expand
IDENTIFICATION BY IMMUNOFLUORESCENCE OF EOSINOPHIL GRANULE MAJOR BASIC PROTEIN IN LUNG TISSUES OF PATIENTS WITH BRONCHIAL ASTHMA
TLDR
Tests suggest that MBP in the eosinophil granule is released into respiratory tissue of patients with severe asthma and that it is associated with tissue damage. Expand
Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis.
TLDR
It is concluded that distinct mechanisms of eosinophilia exist in patients with allergic versus nonallergic CHS/NP and that the allergic mechanism involves production of TH2-type cytokines, including GM-CSF, IL-3, Il-4, and IL-5, by infiltrating T lymphocytes. Expand
Asthma: the irreversible airways disease.
TLDR
Antiinflammatory medications, such as inhaled corticosteroids, have been shown to decrease this rate of decline in lung function, while the effect of bronchodilators is less conclusive. Expand
The diagnosis and incidence of allergic fungal sinusitis.
TLDR
The data presented indicate that the diagnostic criteria for AFS are present in the majority of patients with CRS with or without polyposis, and a change in terminology from AFS to eosinophilic fungal rhinosinusitis is proposed. Expand
Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma
TLDR
Physiology, airway inflammation and remodelling in asthma are interrelated and improve with ICS, even in patients with relatively mild asthma, and the results of this study support the need for early and long term intervention with I CS. Expand
Tissue eosinophilia in chronic sinusitis: quantification techniques.
TLDR
The proposed method for quantifying tissue eosinophilia in sinus mucosa is reliable and valid and a relatively strong correlation exists between CT scan stage and tissue eOSinophiles in chronic rhinosinusitis. Expand
Localization of Eosinophil Granule Major Basic Protein in Chronic Urticaria
TLDR
An indirect immuno-fluorescence assay on sections of formalin-fixed, paraffin-embedded tissue suggests a possible role for the cytotoxic molecule MBP in the evolution of lesions of chronic urticaria. Expand
Airway remodelling in the pathogenesis of asthma.
TLDR
The inflammatory and remodelling processes that underlie asthma result from a highly complex interaction between various cell types, resulting in an increased thickness of the airway wall, leading to a reduced baseline airway calibre and exaggerated airway narrowing. Expand
Cytotoxicity of human eosinophil granule major basic protein to human nasal sinus mucosa in vitro.
TLDR
Results indicate that MBP damages human upper respiratory epithelium, causing ciliostasis and alteration of the epithelial surface at concentrations likely achieved in vivo. Expand
...
1
2
...