Features of Methylation and Gene Expression in the Promoter-Associated CpG Islands Using Human Methylome Data

Abstract

CpG islands are typically located in the 5' end of genes and considered as gene markers because they play important roles in gene regulation via epigenetic change. In this study, we compared the features of CpG islands identified by several major algorithms by setting the parameter cutoff values in order to obtain a similar number of CpG islands in a genome… (More)
DOI: 10.1155/2012/598987

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