Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest

  title={Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest},
  author={G. F. Scott and A. Nguyen and Brandon H. Cherry and Roger A Hollrah and I. Salinas and A. Williams and Myoung-Gwi Ryou and R. Mallet},
  journal={Experimental Biology and Medicine},
  pages={1095 - 1103}
  • G. F. Scott, A. Nguyen, +5 authors R. Mallet
  • Published 2017
  • Medicine
  • Experimental Biology and Medicine
  • Cardiac arrest (CA) and cardiocerebral resuscitation (CCR)-induced ischemia–reperfusion imposes oxidative and carbonyl stress that injures the brain. The ischemic shift to anaerobic glycolysis, combined with oxyradical inactivation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), provokes excessive formation of the powerful glycating agent, methylglyoxal. The glyoxalase (GLO) system, comprising the enzymes glyoxalase 1 (GLO1) and GLO2, utilizes reduced glutathione (GSH) supplied by… CONTINUE READING
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