Feature-by-Feature – Evaluating De Novo Sequence Assembly

Abstract

The whole-genome sequence assembly (WGSA) problem is among one of the most studied problems in computational biology. Despite the availability of a plethora of tools (i.e., assemblers), all claiming to have solved the WGSA problem, little has been done to systematically compare their accuracy and power. Traditional methods rely on standard metrics and read… (More)
DOI: 10.1371/journal.pone.0031002

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