Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila

@article{Saito2001FeasiblePO,
  title={Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila},
  author={Koji Saito and Hiroshi Sudo and Masatoshi Yamazaki and M. Koseki-Nakamura and Madoka Kitajima and Hiroyuki Takayama and Norio Aimi},
  journal={Plant Cell Reports},
  year={2001},
  volume={20},
  pages={267-271}
}
Camptothecin derivatives are used clinically as anti-tumor alkaloids. Camptothecin and its related compounds are at present obtained by extraction from intact plants, but transformed plant cell cultures may be an alternative source of production. We have established a hairy root culture of Ophiorriza pumila (Rubiaceae) transformed by Agrobacterium rhizogenes strain 15834. This hairy root culture grew well, increasing by 16-fold during 5 weeks in liquid culture, and it produced camptothecin as a… CONTINUE READING

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