Feasibility study on protracted infusional 5-fluorouracil and consecutive low-dose cisplatin for advanced gastric cancer.

@article{Kondo1996FeasibilitySO,
  title={Feasibility study on protracted infusional 5-fluorouracil and consecutive low-dose cisplatin for advanced gastric cancer.},
  author={Kenji Kondo and Masahiko Murase and Yasuhiro Kodera and Seiji Akiyama and Katsuki Ito and Yujiro Yokoyama and Hitoshi Takagi and Tetsuhiko Shirasaka},
  journal={Oncology},
  year={1996},
  volume={53 1},
  pages={64-7}
}
In this phase II trial 31 patients with advanced gastric cancer (21 with metastatic cancer and 10 with locally advanced cancer) were treated with a continuous 24-hour infusion of 5-fluorouracil (5-FU) 330 mg/m2/day plus low-dose cisplatin (CDDP) 6 mg/m2/day by bolus infusion on days 1-5. The regimen with a combination of 5-FU and low-dose CDDP (FLDP) was repeated weekly for two to four courses according to response and tolerance. In 24 (77%) of the 31 patients, four courses of this regimen were… CONTINUE READING

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