• Corpus ID: 237491729

Feasibility study of a proton CT system based on 4D-tracking and residual energy determination via time-of-flight

  title={Feasibility study of a proton CT system based on 4D-tracking and residual energy determination via time-of-flight},
  author={Felix Ulrich-Pur and Thomas Bergauer and Alexander Burker and Albert Hirtl and Christian Irmler and Stefanie Kaser and Florian Michael Pitters and Simon Rit},
For dose calculations in ion beam therapy, it is vital to accurately determine the relative stopping power (RSP) distribution within the treated volume. Currently, RSP values are extrapolated from Hounsfield units (HU), measured with x-ray computed tomography (CT), which entails RSP inaccuracies due to conversion errors. A suitable method to improve the treatment plan accuracy is proton computed tomography (pCT). A typical pCT system consists of a tracking system and a separate residual energy… 
1 Citations
Relative stopping power precision in time-of-flight proton CT
Objective Proton computed tomography (CT) is similar to x-ray CT but relies on protons rather than photons to form an image. In its most common operation mode, the measured quantity is the amount of


Experimental comparison of proton CT and dual energy X-ray CT for relative stopping power estimation in proton therapy.
The pCT prototype scanner outperformed a state-of-the-art DECT scanner in terms of RSP accuracy (MAPE) for plastic tissue mimicking inserts since artifacts tended to concentrate in the inserts, their mitigation may lead to further improvements in the reported pCT accuracy.
A proton Computed Tomography based medical imaging system
This paper reports on the activity of the INFN PRIMA/RDH collaboration in the development of proton Computed Tomography (pCT) systems based on single proton tracking and residual energy measurement.
Novel scintillation detector design and performance for proton radiography and computed tomography.
The new multistage design approach to WEPL measurements for proton CT and radiography has been prototyped and tested and the test results show that the design is competitive with much more expensive calorimeter and range-counter designs.
Results from a Prototype Proton-CT Head Scanner
Abstract We are exploring low-dose proton radiography and computed tomography (pCT) as techniques to improve the accuracy of proton treatment planning and to provide artifact-free images for
A High-Granularity Digital Tracking Calorimeter Optimized for Proton CT
A typical proton CT (pCT) detector comprises a tracking system, used to measure the proton position before and after the imaged object, and an energy/range detector to measure the residual proton
Dual-energy CT based proton range prediction in head and pelvic tumor patients.
The magnitude of patient-specific range deviations between HLUT and the more accurate DECT-based SPR prediction is clinically relevant and a clinical application of the latter seems feasible as demonstrated in this study using medically approved systems from CT acquisition to treatment planning.
The precision of proton range calculations in proton radiotherapy treatment planning: experimental verification of the relation between CT-HU and proton stopping power.
It was found that the agreement between measurement and calibration curve is better than 1% if beam hardening effects in the acquisition of the CT images can be neglected and an estimation for the overall range precision of proton beams is given.
A maximum likelihood proton path formalism for application in proton computed tomography.
A compact, matrix-based most likely path (MLP) formalism is presented employing Bayesian statistics and a Gaussian approximation of MCS to predict the Monte Carlo tracks of 200 MeV protons in GEANT4 simulations.
Conceptual design of a proton computed tomography system for applications in proton radiation therapy
Proton computed tomography (pCT) has the potential to improve the accuracy of dose calculations for proton treatment planning, and will also be useful for pretreatment verification of patient
Design optimization of a pixel-based range telescope for proton computed tomography.
  • H. E. S. Pettersen, J. Alme, +30 authors D. Röhrich
  • Medicine, Materials Science
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2019
This study evaluates different design alternatives of the range telescope on basis of the protons' range accuracy and the track reconstruction efficiency and a design recommendation is reached where the proposed range telescope applies 3.5 mm thick aluminum absorber slabs between each sensor layer.