Feasibility studies of utilizing disk intrinsic dissolution rate to classify drugs.

@article{Yu2004FeasibilitySO,
  title={Feasibility studies of utilizing disk intrinsic dissolution rate to classify drugs.},
  author={Lawrence X. Yu and Alan S. Carlin and Gordon L Amidon and A. S. Zahir Hussain},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={270 1-2},
  pages={221-7}
}
The purpose of this report was to investigate the feasibility of using disk intrinsic dissolution rate (DIDR) to determine solubility class membership. We employed a VanKel dissolution apparatus fitted with a Wood's intrinsic dissolution die. To test the robustness of the method, variations of DIDR with compression force, dissolution volume, distance of the… CONTINUE READING