Feasibility of using a surface plasmon resonance-based biosensor to detect and quantify yessotoxin.

@article{Fonfra2008FeasibilityOU,
  title={Feasibility of using a surface plasmon resonance-based biosensor to detect and quantify yessotoxin.},
  author={Eva S. Fonfr{\'i}a and Natalia Vilari{\~n}o and Mercedes Rodr{\'i}guez Vieytes and Takeshi Yasumoto and Luis M. Botana},
  journal={Analytica chimica acta},
  year={2008},
  volume={617 1-2},
  pages={167-70}
}
Yessotoxin (YTX) is a disulfated polyether toxin produced by marine dinoflagellates. Although there is no clear evidence that YTX is toxic to humans, it is a major cause of false positives in DSP toxin detection by mouse bioassay. We developed a new detection and quantification method for yessotoxin using a BiaCore X Surface plasmon resonance (SPR)-based biosensor. The assay is based in the interaction of YTX with phosphodiesterase enzymes (PDE), one of its cellular targets. The injection of… CONTINUE READING

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