Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.

@article{Lisman1988FeasibilityOL,
  title={Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.},
  author={John E. Lisman and Marc A. Goldring},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 14},
  pages={5320-4}
}
The feasibility of long-term information storage by brain type II Ca2+/calmodulin-dependent protein kinase molecules is explored. Recent evidence indicates that this protein has switch-like properties. Equations are derived showing that a single kinase holoenzyme could form a bistable switch having the stability necessary to encode long-term memory, and that a group of kinase molecules, such as that contained within the postsynaptic density, could form a device capable of storing graded… CONTINUE READING

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