• Corpus ID: 5675853

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

@article{Alley1988FeasibilityOD,
  title={Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.},
  author={Michael C. Alley and Dominic A. Scudiero and Anne P Monks and M L Hursey and Maciej Czerwiński and Donald L. Fine and Betty J. Abbott and Joseph G. Mayo and Robert H. Shoemaker and Michael R. Boyd},
  journal={Cancer research},
  year={1988},
  volume={48 3},
  pages={
          589-601
        }
}
For the past 30 years strategies for the preclinical discovery and development of potential anticancer agents have been based largely upon the testing of agents in mice bearing transplantable leukemias and solid tumors derived from a limited number of murine as well as human sources. The feasibility of implementing an alternate approach, namely combined in vitro/in vivo screening for selective cytotoxicity among panels of human tumor cell lines derived from a broad spectrum of human solid… 

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