Feasibility of detecting prostate cancer by ultraperformance liquid chromatography-mass spectrometry serum metabolomics.

@article{Zang2014FeasibilityOD,
  title={Feasibility of detecting prostate cancer by ultraperformance liquid chromatography-mass spectrometry serum metabolomics.},
  author={Xiaoling Zang and Christina M. Jones and Tran Quang Long and Mar{\'i}a Eugenia Monge and Manshui Zhou and L. DeEtte Walker and Roman Mezencev and Alexander G. Gray and John F McDonald and Facundo M. Fern{\'a}ndez},
  journal={Journal of proteome research},
  year={2014},
  volume={13 7},
  pages={3444-54}
}
Prostate cancer (PCa) is the second leading cause of cancer-related mortality in men. The prevalent diagnosis method is based on the serum prostate-specific antigen (PSA) screening test, which suffers from low specificity, overdiagnosis, and overtreatment. In this work, untargeted metabolomic profiling of age-matched serum samples from prostate cancer patients and healthy individuals was performed using ultraperformance liquid chromatography coupled to high-resolution tandem mass spectrometry… CONTINUE READING
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