Feasibility of a sustained steep Ca(2+)Gradient in the cytosol of electrically non-excitable cells.


In electrically non-excitable cells the predominant mode of calcium signaling is a biphasic rise in cytosolic calcium concentration. It results from Ca(2+)release from intracellular stores, followed by Ca(2+)influx across the plasma membrane. It has been hypothesized that prolonged calcium influx may result in a sustained local elevation of the cytosolic… (More)


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