Feasibility of Using a Bone-Targeted, Macromolecular Delivery System Coupled with Prostaglandin E1 to Promote Bone Formation in Aged, Estrogen-Deficient Rats

@article{Miller2008FeasibilityOU,
  title={Feasibility of Using a Bone-Targeted, Macromolecular Delivery System Coupled with Prostaglandin E1 to Promote Bone Formation in Aged, Estrogen-Deficient Rats},
  author={S. C. Miller and Huaizhong Pan and D. Wang and Beth M. Bowman and Pavla Kopec̆kov{\'a} and Jindřich Kope{\vc}ek},
  journal={Pharmaceutical Research},
  year={2008},
  volume={25},
  pages={2889-2895}
}
PurposeMacromolecular delivery systems have therapeutic uses because of their ability to deliver and release drugs to specific tissues. The uptake and localization of HPMA copolymers using Asp8 as the bone-targeting moiety was determined in aged, ovariectomized (ovx) rats. PGE1 was attached via a cathepsin K-sensitive linkage to HPMA copolymer–Asp8 conjugate and was tested to determine if it could promote bone formation.Materials and MethodsThe uptake of FITC-labeled HPMA copolymer–Asp8… 
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