Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD.

@article{Morgan2014FeasibilityAO,
  title={Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD.},
  author={Alexandra R. Morgan and Geoffrey J. M. Parker and Caleb Roberts and Giovanni A. Buonaccorsi and Niall C Maguire and Penny L. Hubbard Cristinacce and Dave Singh and J\orgen Vestbo and Leif Bjermer and Jonas J{\"o}gi and Ziad Taib and Janeli Sarv and Piet L. B. Bruijnzeel and Lars E. Olsson and Eva Bondesson and Ulf Nihl{\'e}n and Deirdre McGrath and Simon S. Young and John C. Waterton and Lars Haug Nordenmark},
  journal={European journal of radiology},
  year={2014},
  volume={83 11},
  pages={2093-101}
}
OBJECTIVES Oxygen-enhanced MRI (OE-MRI) biomarkers have potential value in assessment of COPD, but need further evaluation before treatment-induced changes can be interpreted. The objective was to evaluate how OE-MRI parameters of regional ventilation and oxygen uptake respond to standard pharmacological interventions in COPD, and how the response compares to that of gold standard pulmonary function tests. MATERIALS AND METHODS COPD patients (n=40), mean FEV1 58% predicted normal, received… CONTINUE READING
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