Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors.

  title={Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors.},
  author={Marc E. Horowitz and Larry E. Kun and Raymond K. Mulhern and Edward H. Kovnar and Robert. A. Sanford and B M Hockenberger and F L Greeson and James William Langston and Diane L. Fairclough and Jesse J. Jenkins},
  volume={22 4},
Preirradiation chemotherapy is a potentially important component of combined treatment for brain tumors; however, concerns over its side effects and antitumor activity have impeded its evaluation in clinical trials. To determine the feasibility of administering such therapy to children, we assessed the responses of 38 brain tumor patients (median age, 2 years) to 12 weeks of combination chemotherapy given after surgical resection but before irradiation. Transient myelosuppression was noted in… CONTINUE READING


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