Feasibility and efficacy of chronic transfusion for stroke prevention in children with sickle cell disease

@article{Mirre2010FeasibilityAE,
  title={Feasibility and efficacy of chronic transfusion for stroke prevention in children with sickle cell disease},
  author={Elsa Mirre and Valentine Brousse and Laureline Berteloot and Karen Lambot-Juhan and Suzanne Verlhac and Claire Boulat and Marie Dumont and G{\'e}rard Lenoir and Mariane de Montalembert},
  journal={European Journal of Haematology},
  year={2010},
  volume={84}
}
Objectives:  In children with sickle cell disease (SCD), chronic transfusion to maintain haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when transcranial Doppler (TCD) ultrasonography shows abnormal cerebral blood flow velocities and the risk of recurrent stroke. Maintaining HbS below 30% may be difficult, especially in countries where blood donors and recipients belong to different ethnic groups and where the availability of closely matched blood products is… 
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[Transfusion in children with sickle cell disease].
  • M.-L. Couëc
  • Medicine, Biology
    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
  • 2012
Neurological Complications following Blood Transfusions in Sickle Cell Anemia
TLDR
Cases of SCA who developed neurological complications after a blood transfusion such as Reversible Posterior Leukoencephalopathy Syndrome (RLPS) are highlighted.
How I Treat How I treat and manage strokes in sickle cell disease
TLDR
2 cases, a child and an adult with SCA, presenting with focal neurologic deficit, are described, highlighting inherent challenges in care, while also emphasizing current approaches in the acute, sub-acute, and long-term management of strokes.
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TLDR
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TLDR
Transfusion greatly reduces the risk of a first stroke in children with sickle cell anemia who have abnormal results on transcranial Doppler ultrasonography.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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