Feasibility and challenges in the development of immunocontraceptive vaccine based on zona pellucida glycoproteins.

@article{Choudhury2007FeasibilityAC,
  title={Feasibility and challenges in the development of immunocontraceptive vaccine based on zona pellucida glycoproteins.},
  author={Sangeeta Choudhury and Neelu Srivastava and Partap Singh Narwal and Archana Rath and Sonika Jaiswal and Satish Kumar Gupta},
  journal={Society of Reproduction and Fertility supplement},
  year={2007},
  volume={63},
  pages={479-93}
}
The zona pellucida (ZP) glycoproteins play a crucial role during fertilization and thus are considered as important target antigens for the development of immunocontraceptive vaccines aiming to inhibit fertility at a pre-fertilization stage. In order to evaluate the immunocontraceptive potential of ZP glycoproteins, bonnet monkey (Macaca radiata) ZP2, ZP3 and ZP4 have been cloned and expressed using either E. coli or baculovirus expression systems. Active immunization studies with the… CONTINUE READING