Feasibility and acceptability of an intranasal diamorphine spray as an alternative to injectable diamorphine for maintenance treatment.

@article{Mitchell2006FeasibilityAA,
  title={Feasibility and acceptability of an intranasal diamorphine spray as an alternative to injectable diamorphine for maintenance treatment.},
  author={Timothy B. Mitchell and Nicholas Lintzeris and Alyson J. Bond and John Strang},
  journal={European addiction research},
  year={2006},
  volume={12 2},
  pages={
          91-5
        }
}
An intranasal (IN) diamorphine spray was investigated as a possible alternative to injectable diamorphine for maintenance treatment. Plasma morphine and 6-monoacetylmorphine (6MAM) concentrations and pharmacodynamic responses were measured for 4 h following intravenous (IV) and IN administration of 40 mg diamorphine in 4 patients prescribed injectable diamorphine. The two routes were primarily differentiated by the significantly greater speed and magnitude of peak plasma morphine and 6MAM… CONTINUE READING